The recent classifications of titanium dioxide and carbon black (intended in 2021) and the suggestion that PSLTs (Poorly Soluble Low Toxicity Particles) can be considered as a group for safety classification, raises important questions how best to apply the wealth of inhalation toxicology and epidemiology information developed over the past 30 years. Recently we published a commentary based on a series of 1:1 interviews with experts from the toxicology, epidemiology and regulatory fields to understand their views on topics of PSLT safety including: the definition of PSLTs; lung clearance overload; and, the implications of animal and epidemiological studies. A recent workshop in Edinburgh was organized by Nanoconsult and Health Innovation Partners provided an open forum where experts discussed the state-of-the-art science on PSLT safety and relevance of rat and human lung overload. During the workshop consensus was reached on a large number of important topics, in the presence of observers from industry, academia and regulatory bodies. During the IPTC in Salzburg a first public summary was presented on september 13th. The expert report is now published Open Access in Inhalation Toxicology(Driscoll&Borm-InhalTox(2020).
Paul J.A. Borm & Kevin E. Driscoll