APRIL 1st & 2nd 2019-EDINBURGH (UK)

The recent classifications of titanium dioxide and carbon black (intended in 2021) and the suggestion that PSLTs (Poorly Soluble Low Toxicity Particles) can be considered as a group for safety classification, raises important questions how best to apply the wealth of inhalation toxicology and epidemiology information developed over the past 30 years.  Recently we published a commentary based on a series of 1:1 interviews with experts from the toxicology, epidemiology and regulatory fields to understand their views on topics of PSLT safety including: the definition of PSLTs; lung clearance overload; and, the implications of animal and epidemiological studies.  A recent workshop in Edinburgh was organized by Nanoconsult and Health Innovation Partners provided an open forum where experts  discussed the state-of-the-art science on PSLT safety and relevance of rat and human lung overload.  During the workshop  consensus was reached on a large number of important topics, in the presence of observers from industry, academia and regulatory bodies. During the IPTC in Salzburg a first public summary was presented on september 13th. The expert report is now published Open Access in  Inhalation Toxicology(Driscoll&Borm-InhalTox(2020).

Paul J.A. Borm & Kevin E. Driscoll


  • Panel of 15-20 of the top experts from across academia, regulatory, and industry
  • Invited participants only
  • Open issues discussed and debated by the experts documenting for which topics there is consensus and where disagreement exists
  • Q & A sessions will be recorded and shared

  • Publish the outcome as a state-of-the-art expert opinion paper
  • Moderation and coordination by Driscoll & Borm
  • Observers from all stakeholders including industry and regulatory field



PSLT Toxicology Hazard and Risk– IARC, ECHA, ECETOC, ILSI Documents

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Carbon Black, Titanium Dioxide, and Talc, Vol. 93, 2006.

ECHA, Committee for Risk Assessment, Annex 1.  Background document to the opinion proposing harmonized classification and labelling at the EU level of Titanium Dioxide.  2017

ECHA, Committee for Risk Assessment.  Opinion proposing harmonized classification and labelling at EU level of Titanium Dioxide. 2017.

Poorly Soluble Particle/Lung Overload.  European Centre for Ecotoxicology and Toxicology of Chemical.  ECETOC Technical Report 122.  2014.

Risk Science Institute Workshop Participants ILSI. The relevance of the rat lung response to particle overload for human risk assessment: A workshop consensus report. Inhal Toxicol. 12:1–17, 2000.

Biopersistence of MMVF as example for solubility.
Maxim et al (2006)

ILSI working group on short-term assays for fibrous materials:
ILSI (2005)


Selecting Edinburgh as location of the workshop pays tribute to the great contribution of the Institute of Occupational Medicine (IOM), which celebrates its 50th anniversary, and distinguished academic institutes in Edinburgh in the field of occupational medicine and particle-induced lung diseases. The IOM, Edinburgh Lung and the Environment Group Initiative (ELEGI) and Heriot-Watt University are prestigious members of the inhaled particle community and have hosted many EU meetings, inhaled particle meetings and many other (public) events to raise awareness and foster the exchange of scientific information in the field of inhalation toxicology.

Academic and industrial sponsors

Conference organizers & Moderators

Paul J.A. Borm & Kevin E. Driscoll

Confererence secretariat (local)

Sonia Rafferty, PA to dr Rodger Duffin
Tel: +44 (0)131 242 6582

Local organizing committee:

Dr Rodger Duffin
Centre of Inflammation research, QMRC-UoE
Dr Craig Poland

Centre of Inflammation research, QMRC-UoE
Dr Lang Tran

IOM, Edinburgh

Organizing and Planning Committee:

Dr Rodger Duffin, dr Lang Tran
Dr Len Levy (Cranfield University)
Dr Thomas Gebel (BaUA)
Dr Kevin E. Driscoll (Rutgers University, NY)
Prof. dr. Paul J.A. Borm ( Nanoconsult)