We spent 2 full days with 15 invited experts and 15 observers to discuss the state of the art science on PSLT. In breakout sessions we discussed the definition of PSLT, the definition of overload, the releavnce of the rat as a model for PSLT inhalation toxicology and finally the human [...]
Last night most experts and observers joined us at the reception at St Leonards Hall, where they were welcomed by Paul Borm, Kevin Driscoll and Lang Tran from the IOM as one of our hosts. First bridges are being build.
Charges have been set, Experts have been briefed, observers have signed in, dinner speeches prepared!. We are ready to take off to Edinburgh to discuss the state-of-the art on Poorly Soluble Low Toxicity Particles (PSLT) hosted at the University of Edinburgh Medical Campus. We look forward to meet and great all stakeholders [...]
The hazards and risks of inhaled poorly soluble particles – where do we stand after 30 years of research?
Our commentary on expert opinion on PSLT is now online in Particle & Fibre Toxicology. To (open) access click here.
EU Commission has started a public consultation on the 14. ATP of the CLP Regulation, deadline for input is 8 February 2019. One PSLT is involved, i.e. TiO2 and for this substance the following classification is suggested: Carc. 2, H351 (inhalation), GHS08, Wng, H351 (inhalation), Notes: V and 10 If you want [...]
The classification of TiO2 by the European Chemical Agency in 2017 has initiated a series of events and discussions that forward a workshop on particle overload and the consequences drawn from rodent inhalation studies. After the EU classification of titanium dioxide, the suggestion has been raised that Poorly Soluble particles of [...]
France has withdrawn its intention for harmonized classification of crystalline silica (See ECHA’s registry of intentions: https://echa.europa.eu/registry-of-clh-intentions-until-outcome/-/dislist/details/0b0236e180b9b823) The listed reason for withdrawal: As “work involving exposure to respirable crystalline silica dust” is now included in the Directive 2017/2398/CE, French MSCA considers that the need to propose a classification as carcinogen [...]